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1

Impact of aeration strategy on CHO cell performance during antibody production

Velez-Suberbie, M. Lourdes, Tarrant, Richard D. R., Tait, Andrew S., Spencer, Daniel I. R., Bracewell, Daniel G.

Journal:

Biotechnology Progress

Year:

2013

Language:

english

File:

PDF, 854 KB

english, 2013

2

Differential response in downstream processing of CHO cells grown under mild hypothermic conditions

Tait, Andrew S., Tarrant, Richard D. R., Velez-Suberbie, M. Lourdes, Spencer, Daniel I. R., Bracewell, Daniel G.

Journal:

Biotechnology Progress

Year:

2013

Language:

english

File:

PDF, 367 KB

english, 2013

3

Shear Effects on Aluminum Phosphate Adjuvant Particle Properties in Vaccine Drug Products

Kolade, Olatomirin O., Jin, Wenbin, Tengroth, Charbel, Green, Kenneth D., Bracewell, Daniel G.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 1004 KB

english, 2015

4

Protein A Chromatography Resin Lifetime - Impact of Feed Composition

Pathak, Mili, Lintern, Katherine, Bracewell, Daniel G., Rathore, Anurag S.

Journal:

Biotechnology Progress

Year:

2018

Language:

english

File:

PDF, 2.21 MB

english, 2018

5

Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Nweke, Mauryn C., Rathore, Anurag S., Bracewell, Daniel G.

Journal:

Trends in Biotechnology

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

6

A systematic approach for modeling chromatographic processes—Application to protein purification

Sharon Chan, Nigel Titchener-Hooker, Daniel G. Bracewell, Eva Sørensen

Journal:

Year:

2008

Language:

english

File:

PDF, 457 KB

english, 2008

7

Ultra Scale-Down To Define and Improve the Relationship between Flocculation and Disc-Stack Centrifugation

Alex Berrill, Sa V. Ho, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

8

Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

Hogwood, Catherine EM, Bracewell, Daniel G, Smales, C Mark

Journal:

Current Opinion in Biotechnology

Year:

2014

Language:

english

File:

PDF, 431 KB

english, 2014

9

Understanding the Relationship Between Biotherapeutic Protein Stability and Solid-Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4

Tavakoli-Keshe, Roumteen, Phillips, Jonathan J., Turner, Richard, Bracewell, Daniel G.

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

10

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control

Bracewell, Daniel G., Francis, Richard, Smales, C. Mark

Journal:

Biotechnology and Bioengineering

Year:

2015

Language:

english

File:

PDF, 693 KB

english, 2015

11

Manufacture and characterisation of protein nanoparticles as surrogate virus and VLP mimetics for the optimisation of chromatography media

Joseph, Stephan, Wenger, Lukas, Bracewell, Daniel, Thomas, Owen

Journal:

New Biotechnology

Year:

2016

Language:

english

File:

PDF, 54 KB

english, 2016

12

Measurement of impurities to support process development and manufacture of biopharmaceuticals

Oshinbolu, Sheun, Wilson, Louisa J., Lewis, Will, Shah, Rachana, Bracewell, Daniel G.

Journal:

TrAC Trends in Analytical Chemistry

Year:

2017

Language:

english

File:

PDF, 1.79 MB

english, 2017

13

Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants

Oshinbolu, Sheun, Shah, Rachana, Finka, Gary, Molloy, Mike, Uden, Mark, Bracewell, Daniel G

Journal:

Journal of Chemical Technology & Biotechnology

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

14

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

Martinez, Michael, Spitali, Mari, Norrant, Edith L., Bracewell, Daniel G.

Journal:

Trends in Biotechnology

Year:

2018

Language:

english

File:

PDF, 710 KB

english, 2018

15

Characterisation of porous anodic alumina membranes for ultrafiltration of protein nanoparticles as a size mimic of virus particles

Sharma, Anshul, Bracewell, Daniel G.

Journal:

Journal of Membrane Science

Year:

2019

Language:

english

File:

PDF, 6.30 MB

english, 2019

16

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation

Velez‐Suberbie, M. Lourdes, Morris, Stephen A., Kaur, Kawaljit, Hickey, John M., Joshi, Sangeeta B., Volkin, David B., Bracewell, Daniel G., Mukhopadhyay, Tarit K.

Journal:

Biotechnology Progress

Year:

2020

Language:

english

File:

PDF, 4.73 MB

english, 2020

17

Mass spectrometry to describe product and contaminant adsorption properties for bioprocess development

Alex Berrill, Sa V. Ho, Daniel G. Bracewell

Journal:

Biotechnology and Bioengineering

Year:

2011

Language:

english

File:

PDF, 5.43 MB

english, 2011

18

Factors influencing antibody stability at solid–liquid interfaces in a high shear environment

James G. Biddlecombe, Graeme Smith, Shahid Uddin, Sandrine Mulot, David Spencer, Chris Gee, Brendan C. Fish, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2009

Language:

english

File:

PDF, 221 KB

english, 2009

19

Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles

Gaik Sui Kee, Jing Jin, Bangaru Balasundaram, Daniel G. Bracewell, Narahari S. Pujar, Nigel J. Titchener-Hooker

Journal:

Biotechnology Progress

Year:

2010

Language:

english

File:

PDF, 258 KB

english, 2010

20

Product and contaminant measurement in bioprocess development by SELDI-MS

Alex Berrill, Sa V. Ho, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2010

Language:

english

File:

PDF, 589 KB

english, 2010

21

Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step

Rihab Boushaba, Helen Baldascini, Spyridon Gerontas, Nigel J. Titchener-Hooker, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2011

Language:

english

File:

PDF, 496 KB

english, 2011

22

Dual salt precipitation for the recovery of a recombinant protein from Escherichia coli

Bangaru Balasundaram, Soam Sachdeva, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2011

Language:

english

File:

PDF, 652 KB

english, 2011

23

Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations

Shaukat Ali, Miguel Angel Perez-Pardo, Jean P. Aucamp, Alan Craig, Daniel G. Bracewell, Frank Baganz

Journal:

Biotechnology Progress

Year:

2012

Language:

english

File:

PDF, 917 KB

english, 2012

24

Design and characterization of a microfluidic packed bed system for protein breakthrough and dynamic binding capacity determination

Michael S. Shapiro, Steve J. Haswell, Gary J. Lye, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

25

A methodology for the graphical determination of operating conditions of chromatographic sequences incorporating the trade-offs between purity and yield

Rebecca S. Salisbury, Daniel G Bracewell, Nigel J Titchener-Hooker

Journal:

Journal of Chemical Technology & Biotechnology

Year:

2006

Language:

english

File:

PDF, 720 KB

english, 2006

26

Evaluation of the impact of lipid fouling during the chromatographic purification of virus-like particles from Saccharomyces cerevisiae

Jing Jin, Sunil Chhatre, Nigel J. Titchener-Hooker, Daniel G. Bracewell

Journal:

Journal of Chemical Technology & Biotechnology

Year:

2010

Language:

english

File:

PDF, 285 KB

english, 2010

27

Chemical and biological characterisation of a sensor surface for bioprocess monitoring

Jonathan D. Moore, Miguel A. Perez-Pardo, Jonathan F. Popplewell, Steve J. Spencer, Santanu Ray, Marcus J. Swann, Alex G. Shard, Walis Jones, Anna Hills, Daniel G. Bracewell

Journal:

Biosensors and Bioelectronics

Year:

2011

Language:

english

File:

PDF, 697 KB

english, 2011

28

A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies

Sunil Chhatre, Daniel G. Bracewell, Nigel J. Titchener-Hooker

Journal:

Journal of Chromatography A

Year:

2009

Language:

english

File:

PDF, 990 KB

english, 2009

29

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

Gaudet Matthieu, Remtulla Nina, Jackson Sophie E., Main Ewan R. G., Bracewell Daniel G., Aeppli Gabriel, Dalby Paul A.

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 492 KB

english, 2010

30

Nanofibre fabrication in a temperature and humidity controlled environment for improved fibre consistency

Oliver Hardick, Bob Stevens, Daniel G. Bracewell

Journal:

Journal of Materials Science

Year:

2011

Language:

english

File:

PDF, 777 KB

english, 2011

31

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

Spyridon Gerontas, Magnus Asplund, Rolf Hjorth, Daniel G. Bracewell

Journal:

Journal of Chromatography A

Year:

2010

Language:

english

File:

PDF, 737 KB

english, 2010

32

An automated packed Protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum

Sunil Chhatre, Richard Francis, Daniel G. Bracewell, Nigel J. Titchener-Hooker

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 661 KB

english, 2010

33

Comparison of Techniques for Monitoring Antibody Fragment Production in E. coli Fermentation Cultures

Leigh C. Bowering, Daniel G. Bracewell, Eli Kesharvarz-Moore, Mike Hoare, A. Neil C. Weir

Journal:

Biotechnology Progress

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

34

Quantifying Process Tradeoffs in the Operation of Chromatographic Sequences

Sheau-Huey Ngiam, Daniel G. Bracewell, Yuhong Zhou, Nigel J. Titchener-Hooker

Journal:

Biotechnology Progress

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

35

Bioprocess Engineering Issues That Would Be Faced in Producing a DNA Vaccine at up to 100 m3 Fermentation Scale for an Influenza Pandemic

Mike Hoare, M. Susana Levy, Daniel G. Bracewell, Steven D. Doig, Simyee Kong, Nigel Titchener-Hooker, John M. Ward, Peter Dunnill

Journal:

Biotechnology Progress

Year:

2005

Language:

english

File:

PDF, 172 KB

english, 2005

36

A Framework for the Prediction of Scale-Up When Using Compressible Chromatographic Packings

Richard Tran, John R. Joseph, Andrew Sinclair, Daniel Bracewell, Yuhong Zhou, Nigel J. Titchener-Hooker

Journal:

Biotechnology Progress

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

37

Determining Antibody Stability: Creation of Solid-Liquid Interfacial Effects within a High Shear Environment

James G. Biddlecombe, Alan V. Craig, Hu Zhang, Shahid Uddin, Sandrine Mulot, Brendan C. Fish, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2007

Language:

english

File:

PDF, 260 KB

english, 2007

38

A Microscale Yeast Cell Disruption Technique for Integrated Process Development Strategies

Marc D. Wenger, Peter DePhillips, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2008

Language:

english

File:

PDF, 343 KB

english, 2008

39

An automated microscale chromatographic purification of virus-like particles as a strategy for process development

Marc D. Wenger, Peter DePhillips, Colleen E. Price, Daniel G. Bracewell

Journal:

Biotechnology and Applied Biochemistry

Year:

2007

Language:

english

File:

PDF, 355 KB

english, 2007

40

Report and recommendation of a workshop on education and training for measurement, monitoring, modelling and control (M3C) in biochemical engineering

Daniel Bracewell, Krist V. Gernaey, Jarka Glassey, Volker C. Hass, Elmar Heinzle, Carl-Fredrik Mandenius, Ing-Marie Olsson, Andy Racher, Arne Staby, Nigel Titchener-Hooker

Journal:

Biotechnology Journal

Year:

2010

Language:

english

File:

PDF, 189 KB

english, 2010

41

Soft sensors in bioprocessing: A status report and recommendations

Reiner Luttmann, Daniel G. Bracewell, Gesine Cornelissen, Krist V. Gernaey, Jarka Glassey, Volker C. Hass, Christian Kaiser, Christian Preusse, Gerald Striedner, Prof. Carl-Fredrik Mandenius

Journal:

Biotechnology Journal

Year:

2012

Language:

english

File:

PDF, 197 KB

english, 2012

42

Host cell protein adsorption characteristics during protein a chromatography

Richard D. R. Tarrant, M. Lourdes Velez-Suberbie, Andrew S. Tait, C. Mark Smales, Daniel G. Bracewell

Journal:

Biotechnology Progress

Year:

2012

Language:

english

File:

PDF, 935 KB

english, 2012

43

Study of the conditions for multi-modal chromatographic capture of Fab′ from dual-salt precipitated E. coli homogenate

Bangaru Balasundaram, Sunil Chhatre, Dhruv Arora, Nigel J Titchener-Hooker, Daniel G Bracewell

Journal:

Journal of Chemical Technology & Biotechnology

Year:

2012

Language:

english

File:

PDF, 117 KB

english, 2012

44

Advances in product release strategies and impact on bioprocess design

Bangaru Balasundaram, Sue Harrison, Daniel G. Bracewell

Journal:

Trends in Biotechnology

Year:

2009

Language:

english

File:

PDF, 489 KB

english, 2009

45

The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process

Catherine E.M. Hogwood, Andrew S. Tait, Nadejda Koloteva-Levine, Daniel G. Bracewell, C. Mark Smales

Journal:

Biotechnology and Bioengineering

Year:

2012

Language:

english

File:

PDF, 666 KB

english, 2012

46

A monolith purification process for virus-like particles from yeast homogenate

Claire S. Burden, Jing Jin, Aleš Podgornik, Daniel G. Bracewell

Journal:

Journal of Chromatography B

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

47

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

Candy K.S. Ng, Hector Osuna-Sanchez, Eric Valéry, Eva Sørensen, Daniel G. Bracewell

Journal:

Journal of Chromatography B

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

48

Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Close, Edward J., Salm, Jeffrey R., Iskra, Timothy, Sørensen, Eva, Bracewell, Daniel G.

Journal:

Biotechnology and Bioengineering

Year:

2013

Language:

english

File:

PDF, 605 KB

english, 2013

49

The challenges of product- and process-related impurities to an evolving biopharmaceutical industry

Bracewell, Daniel G, Smales, C Mark

Journal:

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

50

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

Abe, Yuki, Gor, Jayesh, Bracewell, Daniel G., Perkins, Stephen J., Dalby, Paul A.

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 1.57 MB

english, 2010